Lyrica 200mg

Lyrica is an anti-epileptic drug, also called an anticonvulsant. It works by slowing down impulses in the brain that cause seizures. Pregabalin also affects chemicals in the brain that send pain signals across the nervous system.

Pregabalin is used to treat pain caused by fibromyalgia, or nerve pain in people with diabetes (diabetic neuropathy), herpes zoster (post-herpetic neuralgia), or spinal cord injury.

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Pregabalin : Lyrica, Zerica, Gabica, Xilica

Pregabalin is used to treat pain caused by nerve damage due to diabetes or to shingles (herpes zoster) infection. It may also be used to treat nerve pain caused by spinal cord injury.

This medication is also used to treat pain in people with fibromyalgia. Pregabalin is also used with other medications to treat certain types of seizures (partial onset seizures).

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KEEP IN MIND LYRICA iS A CONTROLLED SUBSTANCE. SCHEDULE 5.
DUE TO LAWS AND REGULATIONS YOUR ORDER WILL BE REVIEWED BY A PHYSICIAN.
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YOU WILL NOT BE CHARGED IF IN ANY CASE YOUR ORDER IS EVER DECLINED.
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Lyrica 200mg - Ascend Laboratories LLC Brand
Quantity	Price
30Qty	$225.00
60Qty	$255.00
90Qty	$285.00

PREGABALIN is used with other medicines to help control partial-onset seizures (convulsions) in the treatment of epilepsy in patients 1 month of age and older. This medicine will not cure epilepsy and will only work to control seizures for as long as you continue to take it.

IMPORTANT INFORMATION:
Source: https://www.drugs.com/pregabalin.html

Warnings

Pregabalin can cause a severe allergic reaction. Stop taking pregabalin and seek emergency medical help if you have hives or blisters on your skin, trouble breathing, or swelling in your face, mouth, or throat.

Some people have thoughts about suicide while taking pregabalin. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

If you have diabetes or heart problems, call your doctor if you have weight gain or swelling in your hands or feet while taking pregabalin.

Do not stop using pregabalin suddenly, even if you feel fine. Stopping suddenly may cause withdrawal symptoms.

HOW TO USE PREGABALIN
Source: https://labeling.pfizer.com/showlabeling.aspx?id=561

Pregabalin is indicated for:

Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
Postherpetic neuralgia (PHN)
Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
Fibromyalgia
Neuropathic pain associated with spinal cord injury

DOSAGE AND ADMINISTRATION

For adult indications, begin dosing at 150 mg/day. For partial-onset seizure dosing in pediatric patients 1 month of age and older
Dosing recommendations:

INDICATION	Dosing Regimen	Maximum Dose
DPN Pain	3 divided doses per day	300 mg/day within 1 week
PHN	2 or 3 divided doses per day	300 mg/day within 1 week. Maximum dose of 600 mg/day.
Adjunctive Therapy for Partial-Onset Seizures in Pediatric and Adult Patients Weighing 30 kg or More	2 or 3 divided doses per day	Maximum dose of 600 mg/day.
Adjunctive Therapy for Partial-Onset Seizures in Pediatric Patients Weighing Less than 30 kg	1 month to less than 4 years: 3 divided doses per day 4 years and older: 2 or 3 divided doses per day	14 mg/kg/day.
Fibromyalgia	2 divided doses per day	300 mg/day within 1 week. Maximum dose of 450 mg/day.
Neuropathic Pain Associated with Spinal Cord Injury	2 divided doses per day	300 mg/day within 1 week. Maximum dose of 600 mg/day.

Dose should be adjusted in adult patients with reduced renal function.

DOSAGE FORMS AND STRENGTHS

Capsules: 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, and 300 mg.

CONTRAINDICATIONS

Known hypersensitivity to pregabalin or any of its components.

WARNINGS AND PRECAUTIONS

Angioedema (e.g., swelling of the throat, head and neck) can occur, and may be associated with life-threatening respiratory compromise requiring emergency treatment. Discontinue PREGABALIN immediately in these cases.
Hypersensitivity reactions (e.g., hives, dyspnea, and wheezing) can occur. Discontinue PREGABALIN immediately in these patients.
Antiepileptic drugs, including PREGABALIN, increase the risk of suicidal thoughts or behavior.
Respiratory depression: May occur with PREGABALIN, when used with concomitant CNS depressants or in the setting of underlying respiratory impairment. Monitor patients and adjust dosage as appropriate.
PREGABALIN may cause dizziness and somnolence and impair patients' ability to drive or operate machinery.
Increased seizure frequency or other adverse reactions may occur if PREGABALIN is rapidly discontinued. Withdraw PREGABALIN gradually over a minimum of 1 week.
PREGABALIN may cause peripheral edema. Exercise caution when co-administering PREGABALIN and thiazolidinedione antidiabetic agents.

ADVERSE REACTIONS

Most common adverse reactions (greater than or equal to 5% and twice placebo) in adults are dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and thinking abnormal (primarily difficulty with concentration/attention).

Most common adverse reactions (greater than or equal to 5% and twice placebo) in pediatric patients for the treatment of partial-onset seizures are increased weight and increased appetite.

To report SUSPECTED ADVERSE REACTIONS, contact Pfizer Inc. at 1-800-438-1985 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

USE IN SPECIFIC POPULATIONS

Pregnancy: May cause fetal harm. Advise of potential risk to the fetus.
Lactation: Breastfeeding is not recommended.

What is the most important information I should know about PREGABALIN? PREGABALIN may cause serious side effects including:
serious, even life-threatening, allergic reactions suicidal thoughts or actions serious breathing problems			swelling of your hands, legs and feet dizziness and sleepiness
These serious side effects are described below: Serious, even life-threatening, allergic reactions. Stop taking PREGABALIN and call your healthcare provider right away if you have any of these signs of a serious allergic reaction: swelling of your face, mouth, lips, gums, tongue, throat or neck trouble breathing rash, hives (raised bumps) or blisters Like other antiepileptic drugs, PREGABALIN may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:
	thoughts about suicide or dying attempts to commit suicide new or worse depression new or worse anxiety feeling agitated or restless panic attacks	trouble sleeping (insomnia) new or worse irritability acting aggressive, being angry, or violent acting on dangerous impulses an extreme increase in activity and talking (mania) other unusual changes in behavior or mood
	If you have suicidal thoughts or actions, do not stop PREGABALIN without first talking to a healthcare provider. Stopping PREGABALIN suddenly can cause serious problems. Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes. How can I watch for early symptoms of suicidal thoughts and actions? Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. Keep all follow-up visits with your healthcare provider as scheduled. Call your healthcare provider between visits as needed, especially if you are worried about symptoms.
Serious breathing problems can occur when PREGABALIN is taken with other medicines that can cause severe sleepiness or decreased awareness, or when it is taken by someone who already has breathing problems. Watch for increased sleepiness or decreased breathing when starting PREGABALIN or when the dose is increased. Get help right away if breathing problems occur. Swelling of your hands, legs and feet. This swelling can be a serious problem for people with heart problems. Dizziness and sleepiness. Do not drive a car, work with machines, or do other dangerous activities until you know how LYRICA affects you. Ask your healthcare provider about when it will be okay to do these activities.

DOSAGE FORMS AND STRENGTHS

Capsules: 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, and 300 mg

Usual Adult Dose for:
Source: https://labeling.pfizer.com/showlabeling.aspx?id=561

DOSAGE AND ADMINISTRATION

2.1 Important Administration Instructions

PREGABALIN is given orally with or without food.

When discontinuing PREGABALIN, taper gradually over a minimum of 1 week.

Because PREGABALIN is eliminated primarily by renal excretion, adjust the dose in adult patients with reduced renal function.

2.2 Neuropathic Pain Associated with Diabetic Peripheral Neuropathy in Adults

The maximum recommended dose of PREGABALIN is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Begin dosing at 50 mg three times a day (150 mg/day). The dose may be increased to 300 mg/day within 1 week based on efficacy and tolerability.

Although PREGABALIN was also studied at 600 mg/day, there is no evidence that this dose confers additional significant benefit and this dose was less well tolerated. In view of the dose-dependent adverse reactions, treatment with doses above 300 mg/day is not recommended.

2.3 Postherpetic Neuralgia in Adults

The recommended dose of PREGABALIN is 75 to 150 mg two times a day, or 50 to 100 mg three times a day (150 to 300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Begin dosing at 75 mg two times a day, or 50 mg three times a day (150 mg/day). The dose may be increased to 300 mg/day within 1 week based on efficacy and tolerability.

Patients who do not experience sufficient pain relief following 2 to 4 weeks of treatment with 300 mg/day, and who are able to tolerate PREGABALIN, may be treated with up to 300 mg two times a day, or 200 mg three times a day (600 mg/day). In view of the dose-dependent adverse reactions and the higher rate of treatment discontinuation due to adverse reactions, reserve dosing above 300 mg/day for those patients who have on-going pain and are tolerating 300 mg daily.

2.4 Adjunctive Therapy for Partial-Onset Seizures in Patients 1 Month of Age and Older

The recommended dosages for adults and pediatric patients 1 month of age and older are included in Table 1. Administer the total daily dosage orally in two or three divided doses as indicated in Table 1. In pediatric patients, the recommended dosing regimen is dependent upon body weight. Based on clinical response and tolerability, dosage may be increased, approximately weekly.

Table 1. Recommended Dosage for Adults and Pediatric Patients 1 Month and Older
Age and Body Weight	Recommended Initial Dosage	Recommended Maximum Dosage	Frequency of Administration
Adults (17 years and older)	150 mg/day	600 mg/day	2 or 3 divided doses
Pediatric patients weighing 30 kg or more	2.5 mg/kg/day	10 mg/kg/day (not to exceed 600 mg/day)	2 or 3 divided doses
Pediatric patients weighing less than 30 kg	3.5 mg/kg/day	14 mg/kg/day	1 month to less than 4 years of age: 3 divided doses 4 years of age and older: 2 or 3 divided doses

Both the efficacy and adverse event profiles of PREGABALIN have been shown to be dose-related.

The effect of dose escalation rate on the tolerability of PREGABALIN has not been formally studied.

The efficacy of adjunctive PREGABALIN in patients taking gabapentin has not been evaluated in controlled trials. Consequently, dosing recommendations for the use of PREGABALIN with gabapentin cannot be offered.

2.5 Management of Fibromyalgia in Adults

The recommended dose of PREGABALIN for fibromyalgia is 300 to 450 mg/day. Begin dosing at 75 mg two times a day (150 mg/day). The dose may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability. Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg two times a day (450 mg/day). Although PREGABALIN was also studied at 600 mg/day, there is no evidence that this dose confers additional benefit and this dose was less well tolerated. In view of the dose-dependent adverse reactions, treatment with doses above 450 mg/day is not recommended.

2.6 Neuropathic Pain Associated with Spinal Cord Injury in Adults

The recommended dose range of PREGABALIN for the treatment of neuropathic pain associated with spinal cord injury is 150 to 600 mg/day. The recommended starting dose is 75 mg two times a day (150 mg/day). The dose may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability. Patients who do not experience sufficient pain relief after 2 to 3 weeks of treatment with 150 mg two times a day and who tolerate PREGABALIN may be treated with up to 300 mg two times a day

2.7 Dosing for Adult Patients with Renal Impairment

In view of dose-dependent adverse reactions and since PREGABALIN is eliminated primarily by renal excretion, adjust the dose in adult patients with reduced renal function. The use of PREGABALIN in pediatric patients with compromised renal function has not been studied.

Base the dose adjustment in patients with renal impairment on creatinine clearance (CLcr), as indicated in Table 2. To use this dosing table, an estimate of the patient's CLcr in mL/min is needed. CLcr in mL/min may be estimated from serum creatinine (mg/dL) determination using the Cockcroft and Gault equation:

Next, refer to the Dosage and Administration section to determine the recommended total daily dose based on indication, for a patient with normal renal function (CLcr greater than or equal to 60 mL/min). Then refer to Table 2 to determine the corresponding renal adjusted dose.

(For example: A patient initiating PREGABALIN therapy for postherpetic neuralgia with normal renal function (CLcr greater than or equal to 60 mL/min), receives a total daily dose of 150 mg/day pregabalin. Therefore, a renal impaired patient with a CLcr of 50 mL/min would receive a total daily dose of 75 mg/day pregabalin administered in two or three divided doses.)

For patients undergoing hemodialysis, adjust the pregabalin daily dose based on renal function. In addition to the daily dose adjustment, administer a supplemental dose immediately following every 4-hour hemodialysis treatment

Table 2. Pregabalin Dosage Adjustment Based on Renal Function
Creatinine Clearance (CLcr) (mL/min)	Total Pregabalin Daily Dose (mg/day)*				Dose Regimen
TID= Three divided doses; BID = Two divided doses; QD = Single daily dose.
* Total daily dose (mg/day) should be divided as indicated by dose regimen to provide mg/dose. † Supplementary dose is a single additional dose.

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