Gabapentin
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Gabapentin (sold under the brand name Neurontin, among others) is a medication which is used to treat partial seizures, neuropathic pain, hot flashes, and restless legs syndrome. It is recommended as one of a number of first-line medications for the treatment of neuropathic pain caused by diabetic neuropathy, postherpetic neuralgia, and central neuropathic pain

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Gabapentin : Neurontin, Gabarone, Gralise, Horizant

Gabapentin is used with other medications to prevent and control seizures. It is also used to relieve nerve pain following shingles (a painful rash due to herpes zoster infection) in adults. Gabapentin is known as an anticonvulsant or antiepileptic drug.

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GABAPENTIN is an anti-epileptic drug, also called an anticonvulsant. It affects chemicals and nerves in the body that are involved in the cause of seizures and some types of pain.

Gabapentin is used in adults to treat neuropathic pain (nerve pain) caused by herpes virus or shingles (herpes zoster).

The Horizant brand of gabapentin is also used to treat restless legs syndrome (RLS).

The Neurontin brand of gabapentin is also used to treat seizures in adults and children who are at least 3 years old.

IMPORTANT INFORMATION:
Source: https://www.drugs.com/gabapentin.html
Some people have thoughts about suicide while taking this medicine. Children taking gabapentin may have behavior changes. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Do not stop using gabapentin suddenly, even if you feel fine.



HOW TO USE GABAPENTIN
Source: https://www.webmd.com/drugs/2/drug-14208-8217/gabapentin-oral/gabapentin-oral/details
Take this medication by mouth with or without food as directed by your doctor. Dosage is based on your medical condition and response to treatment. For children, the dosage is also based on weight.

If you are taking the tablets and your doctor directs you to split the tablet in half, take the other half-tablet at your next scheduled dose. Discard half tablets if not used within several days of splitting them. If you are taking the capsules, swallow them whole with plenty of water.

It is very important to follow your doctor's dosing instructions exactly. During the first few days of treatment, your doctor may gradually increase your dose so your body can adjust to the medication. To minimize side effects, take the very first dose at bedtime.

Take this medication regularly to get the most benefit from it. This drug works best when the amount of medicine in your body is kept at a constant level. Therefore, take gabapentin at evenly spaced intervals at the same time(s) each day. If you are taking this medication 3 times a day to control seizures, do not let more than 12 hours pass between doses because your seizures may increase.

Do not take this medication more often or increase your dose without consulting your doctor. Your condition will not improve any faster and the risk of serious side effects may increase.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased.

Antacids containing aluminum or magnesium may interfere with the absorption of this medication. Therefore, if you are also taking an antacid, it is best to take gabapentin at least 2 hours after taking the antacid.

Different forms of gabapentin (such as immediate-release, sustained-release, enacarbil sustained-release) are absorbed in the body differently. Do not switch from one form to the other without consulting your doctor.

Tell your doctor if your condition does not improve or if it worsens.

BEFORE TAKING THIS MEDICATION:

You should not use gabapentin if you are allergic to it.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • kidney disease (or if you are on dialysis);

  • diabetes;

  • depression, a mood disorder, or suicidal thoughts or actions;

  • a seizure (unless you take gabapentin to treat seizures);

  • liver disease;

  • heart disease; or

  • (for patients with RLS) if you are a day sleeper or work a night shift.

  • Some people have thoughts about suicide while taking this medicine. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

    It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

    Seizure control is very important during pregnancy, and having a seizure could harm both mother and baby. Do not start or stop taking gabapentin for seizures without your doctor's advice, and tell your doctor right away if you become pregnant.

    Gabapentin can pass into breast milk, but effects on the nursing baby are not known. Tell your doctor if you are breast-feeding.

    SIDE EFFECTS

    Drowsiness, dizziness, loss of coordination, tiredness, blurred/double vision, unusual eyemovements, or shaking (tremor) may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

    Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

    Tell your doctor right away if any of these unlikely but serious side effects occur: swelling of the hands/ankles/feet.

    A small number of people who take anticonvulsants for any condition (such as seizures, bipolar disorder, pain) may experience depression, suicidal thoughts/attempts, or other mental/mood problems. Tell your doctor right away if you or your family/caregiver notice any unusual/sudden changes in your mood, thoughts, or behavior including signs of depression, suicidal thoughts/attempts, thoughts about harming yourself.

    Get medical help right away if you have any very serious side effects, including: slow/shallow breathing.

    A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.


    Applies to the following strengths: 800 mg; 600 mg; 100 mg; 300 mg; 400 mg; 250 mg/5 mL; enacarbil 600 mg; 300 mg/24 hours; 600 mg/24 hours; 300 mg/24 hours-600 mg/24 hours; enacarbil 300 mg

    Usual Adult Dose for:
    Source: https://www.drugs.com/dosage/gabapentin.html

    Initial dose: 300 mg orally on day one, 300 mg orally 2 times day on day two, then 300 mg orally 3 times a day on day three
    Maintenance dose: 300 to 600 mg orally 3 times a day
    Maximum dose: 3600 mg orally daily (in 3 divided doses)
    -Maximum time between doses in the 3 times a day schedule should not exceed 12 hours

    -The safety and effectiveness of gabapentin available under the trade name Gralise (R) or Horizant (R) in patients with epilepsy has not been studied.

    Comment:
    -May be taken with or without food.
    -Half-tablets not used within 28 days of breaking the scored tablet should be discarded.

    Use: Adjunctive therapy in the treatment of partial onset seizures, with and without secondary generalization

    -Initial dose: 300 mg orally on day one, 300 mg orally 2 times day on day two, then 300 mg orally 3 times a day on day three
    -Titrate up as needed for pain relief
    -Maximum dose: 1800 mg per day (600 mg orally 3 times a day)
    COMMENT:
    -May be taken with or without food.
    -Half-tablets not used within 28 days of breaking the scored tablet should be discarded.

    Gabapentin available under the trade name GRALISE (R):
    -Maintenance dose: Gralise (R) should be titrated to 1800 mg orally once daily with the evening meal.
    -Recommended titration schedule:
    Day 1: 300 mg orally with the evening meal
    Day 2: 600 mg orally with the evening meal
    Days 3 through 6: 900 mg orally with the evening meal
    Days 7 through 10: 1200 mg orally with the evening meal
    Days 11 through 14: 1500 mg orally with the evening meal
    Day 15: 1800 mg orally with the evening meal
    COMMENT:
    -Gralise (R) is not interchangeable with other gabapentin products because of differing pharmacokinetic profiles that affect the frequency of administration.

    Gabapentin enacarbil extended release tablets are available under the trade name HORIZANT (R):
    -The recommended dosage is 600 mg orally 2 times a day. Therapy should be initiated at a dose of 600 mg orally in the morning for 3 days of therapy, then increased to 600 mg 2 times a day (1200 mg/day) on day four.
    COMMENT:
    Gabapentin enacarbil extended release tablets available under the trade name Horizant (R) and gabapentin are not interchangeable.

    Use: Postherpetic neuralgia

    Gabapentin enacarbil available under the trade name Horizant (R):
    600 mg orally once daily with food at about 5 PM

    Comment:
    -May be taken with or without food.

    Use: For the treatment of moderate-to-severe primary Restless Legs Syndrome (RLS) in adults

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